Movie star Vincent Chase, together with his boys Eric, Turtle, and Johnny, are back - and back in business with super agent-turned-studio head Ari Gold on a risky project that will serve as Vince's directorial debut.
Three 40-something best friends from Los Angeles are flying to Paris when their plane makes an emergency landing in Cleveland. Realizing that all the norms from Los Angeles don't apply anymore, they decide to celebrate a city that values real women and stay where they're still considered hot.
Mei, a young girl whose memory holds a priceless numerical code, finds herself pursued by the Triads, the Russian mob, and corrupt NYC cops. Coming to her aid is an ex-cage fighter whose life was destroyed by the gangsters on Mei's trail.